Changes in Inhibition and Valuation After Eating

ID#: NCT05995496

Age: 18 - 45 years

Gender: Female

Healthy Subjects: Accepts Healthy Volunteers

Study Phase: N/A

Recruitment Status: Recruiting

Start Date: December 12, 2023

End Date: December 31, 2027

Contact Information:
Jiulin Dai, B.S.
212-824-9561
Riley Macks
(212) 824-9545
Summary: An impaired ability to exert control has been implicated in bulimia nervosa (BN), but this impairment may not represent a stable trait or be the most effective focus for treatment. This project aims to understand how predictions and value-based decisions about control may be abnormally influenced by eating in individuals with BN, thereby maintaining cycles of binge eating, purging, and restriction.
Eligibility:

Inclusion Criteria:

- Female

- Aged 18 to 45 years

- Current BMI greater than or equal to 18.5kg/m2 but under 30kg/m2

- Right-handed

- English-speaking Additional Inclusion Criteria for Women with Bulimia Nervosa:

- Meet DSM-5 criteria for bulimia nervosa

Exclusion Criteria:

- Medical instability

- Ongoing medical treatment, medical condition, or psychiatric disorder that may interfere with study variables or participation

- Shift work

- Pregnancy, planned pregnancy, or lactation during the study period

- Allergy to any of the ingredients in or unwillingness to consume the standardized meal or unwillingness to drink water during the fasting period

- Any contraindication for fMRI
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