Electrophysiological Read-Out of Interoceptive Processing
Study Phase: Early Phase 1
Recruitment Status: Enrolling by invitation
Start Date: August 10, 2022
End Date: March 31, 2024
Inclusion Criteria:
- Epileptologists at Mount Sinai West have identified the patient as having drug-resistant epilepsy that may benefit from surgery
- Patient has or will undergo invasive monitoring as part of routine surgical management
- Patient has or will be implanted with a minimum of 6-8 bilateral SEEG pairs, including posterior and anterior insula, and at least four of the following targets:
- ventral lateral prefrontal cortex
- dorsal medial prefrontal cortex
- mid-cingulate
- subcallosal cingulate
- amygdala
- hippocampus
- fusiform gyrus
- Sufficient use of hands to complete self-report questionnaires and tasks, as determined during pre-surgical neuropsychological assessment
- Normal or corrected to normal vision, determined by patient report
- Use of anti-epileptic drugs (AEDs) with known psychiatric complications will not be an exclusion criterion
Exclusion Criteria:
- Pre-operative neuropsychological testing indicates a Montreal Cognitive Assessment (MOCA) score < 26.
- English language proficiency insufficient to complete psychometric questionnaires and receive task instructions (<6th grade reading level) as determined by neuropsychologist at pre-operative assessment
- Vulnerable populations such as minors, pregnant women, cognitive impaired individuals and prisoners will not be included in the study
-
Conditions:
- Drug Resistant Epilepsy