The Effect of a Lighting Intervention on Sleep in Parkinson Disease
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to
assess sleep disturbances. For this, participants will wear an Actigraph for seven days.
Thirty of these participants with sleep disturbance will go on to receive a tailored...
Age: 18 years - 66+
Gender: All
Lighting Intervention to Improve Sleep
50 participants with Parkinson's disease will be recruited to complete actigraphy studies to
assess sleep disturbances. For this, participants will wear an Actigraph for seven days.
Thirty of these participants with sleep disturbance, will go on to receive a tailore...
Age: 18 years - 66+
Gender: All
A Study to Assess if BIIB122 Tablets Are Safe and Can Slow Worsening of Early-Stage Parkinson's Disease in Participants With Specific LRRK2 Genetic Variants Between the Ages of 30 and 80 Using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale
In this study, researchers will learn more about a study drug called BIIB122 in participants
with early-stage Parkinson's disease (PD). The study will focus on participants with a
specific genetic variant in their LRRK2 gene.
The main question researchers are tr...
Age: 30 - 80 years
Gender: All
LRRK2, GBA and Other Genetic Biomarkers in Eastern European (Ashkenazi) Jews With and Without Parkinson's Disease
Single site observational study focused on elucidating the genes and biochemical pathways
involved in causing Parkinson disease.
Age: 30 years - 66+
Gender: All
PPMI Clinical - Establishing a Deeply Phenotyped PD Cohort
The Parkinson Progression Marker Initiative (PPMI) is a longitudinal, observational,
multi-center natural history study to assess progression of clinical features, digital
outcomes, and imaging, biologic and genetic markers of Parkinson's disease (PD)
progression in ...
Age: 30 years - 66+
Gender: All
Phase 1/2a Clinical Trial of PR001 (LY3884961) in Patients With Parkinson's Disease With at Least One GBA1 Mutation (PROPEL)
Study J3Z-MC-OJAA is a Phase 1/2a, multicenter, open-label, ascending dose, first in-human
study that will evaluate the safety of intracisternal LY3884961 administration in patients
with moderate to severe Parkinson's disease with at least 1 pathogenic GBA1 mutation...
Age: 35 - 80 years
Gender: All
A Clinical Trial Investigating the Efficacy, Safety and Tolerability of Continuous Subcutaneous ND0612 Infusion in Comparison to Oral IR-LD/CD in Subjects With Parkinson's Disease Experiencing Motor Fluctuations (BouNDless).
This is a multi-center, randomized, double blind, active controlled clinical Study. Following
a screening period, eligible subjects will be enrolled to an open-label oral IR LD/CD
adjustment period; then an open-label ND0612 conversion period; then after optimizatio...
Age: 30 - 80 years
Gender: All
Trial of Parkinson's and Zoledronic Acid
This home-based study is a randomized (1:1) placebo-controlled trial of a single infusion
of zoledronic acid-5 mg (ZA) for the prevention of fractures in men and women aged 60
years and older with Parkinson's disease and parkinsonism with at least 2 years of
follow-u...
Age: 60 years - 66+
Gender: All
Nilotinib in Parkinson's Disease
This study will assess the safety and tolerability of daily oral administration of nilotinib
(150-300mg once daily) in Parkinson's Disease.
Age: 40 - 79 years
Gender: All