Lung disease
Lung disease is any problem in the lungs that prevents the lungs from working properly. There are three main types of lung disease:
- Airway diseases -- These diseases affect the tubes (airways) that carry oxygen and other gases into and out of the lungs. They usually cause a narrowing or blockage of the airways. Airway diseases include asthma, chronic obstructive pulmonary disease (COPD), bronchiolitis, and bronchiectasis (which also is the main disorder for persons with cystic fibrosis). People with airway diseases often say they feel as if they're "trying to breathe out through a straw."
- Lung tissue diseases -- These diseases affect the structure of the lung tissue. Scarring or inflammation of the tissue makes the lungs unable to expand fully (restrictive lung disease). This makes it hard for the lungs to take in oxygen and release carbon dioxide. People with this type of lung disorder often say they feel as if they are "wearing a too-tight sweater or vest." As a result, they can't breathe deeply. Pulmonary fibrosis and sarcoidosis are examples of lung tissue disease.
- Lung circulation diseases -- These diseases affect the blood vessels in the lungs. They are caused by clotting, scarring, or inflammation of the blood vessels. They affect the ability of the lungs to take up oxygen and release carbon dioxide. These diseases may also affect heart function. An example of a lung circulation disease is pulmonary hypertension. People with these conditions often feel very short of breath when they exert themselves.
Many lung diseases involve a combination of these three types.
The most common lung diseases include:
- Asthma
- Collapse of part or all of the lung (pneumothorax or atelectasis)
- Swelling and inflammation in the main passages (bronchial tubes) that carry air to the lungs (bronchitis)
- COPD
- Lung cancer
- Lung infection (pneumonia)
- Abnormal buildup of fluid in the lungs (pulmonary edema)
- Blocked lung artery (pulmonary embolus)
This individual has a mass in the upper part of the lung. Although the cause of the mass can be suspected, based on this person's history, there are many diseases that can produce lung lesions.
This is a CT scan of the upper chest showing a mass in the right lung (seen on the left side of the picture).
This picture is a chest X-ray of a person with a lung mass. This is a front view, where the lungs are the two dark areas and the heart and other structures are visible in the middle of the chest. The X-ray shows a mass in the right upper lung, indicated with the arrow (seen on the left side of the picture).
This CT scan shows a cross section of the lungs of a person with lung cancer. The two dark areas in the middle of the screen are the lungs. The light areas in the right lung (on the left of the screen) represent the cancer.
Secondhand smoke has been classified as a known cause of lung cancer in humans (Group A carcinogen).
Yellow nail syndrome is characterized by yellow nails that lack a cuticle, grow slowly, and are loose or detached (onycholysis). Yellow nail syndrome is most commonly associated with lung disorders, and with lymphedema.
Air is breathed in through the nasal passageways, travels through the trachea and bronchi to the lungs.
References
Clifton IJ, Ellames DAB. Respiratory medicine. In: Penman ID, Ralston SH, Strachan MWJ, Hobson RP, eds. Davidson's Principles and Practice of Medicine. 24th ed. Philadelphia, PA: Elsevier; 2022:chap 17.
Kraft M. Approach to the patient with respiratory disease. In: Goldman L, Schafer AI, eds. Goldman-Cecil Medicine. 26th ed. Philadelphia, PA: Elsevier; 2020:chap 77.
Version Info
Last reviewed on: 7/31/2022
Reviewed by: Denis Hadjiliadis, MD, MHS, Paul F. Harron Jr. Professor of Medicine, Pulmonary, Allergy, and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
