Cerebral amyloid angiopathy
Amyloidosis - cerebral; CAA; Congophilic angiopathy
Cerebral amyloid angiopathy (CAA) is a condition in which proteins called amyloid build up on the walls of the arteries in the brain. CAA causes bleeding into the brain (hemorrhagic stroke) and dementia.
The internal carotid arteries and the vertebral arteries supply blood to the brain.
Causes
People with CAA have deposits of amyloid protein in the walls of blood vessels in the brain. The protein is usually not deposited anywhere else in the body.
The major risk factor is increasing age. CAA is more often seen in people older than 55. Sometimes, it is passed down through families.
Symptoms
CAA can cause bleeding into the brain. Bleeding often occurs in the outer parts of the brain, called the cortex, and not the deep areas. Symptoms occur because bleeding in the brain harms brain tissue. Some people have gradual memory problems. When a CT scan is done, there are often signs that they have had bleeding in the brain that they may not have realized.
If there is a lot of bleeding, immediate symptoms occur and resemble a stroke. These symptoms include:
- Drowsiness
- Headache (usually in a certain part of the head)
- Nervous system changes that may start suddenly, including confusion, delirium, double vision, decreased vision, sensation changes, speech problems, weakness, or paralysis
- Seizures
- Stupor or coma (rarely)
- Vomiting
If bleeding is not severe or widespread, symptoms can include:
- Episodes of confusion
- Headaches that come and go
- Loss of mental function (dementia)
- Weakness or unusual sensations that come and go, and involve smaller areas
- Seizures
Exams and Tests
CAA is hard to diagnose with certainty without a sample of brain tissue. This is usually done after death or when a biopsy of the blood vessels of the brain is done.
A physical exam can be normal if the bleed is small. There may be some brain function changes. It is important for the doctor to ask detailed questions about the symptoms and medical history. The symptoms and results of the physical exam and any imaging tests may cause the doctor to suspect CAA.
Imaging tests of the head that may be done include:
Treatment
There is no known effective treatment. The goal of treatment is to relieve symptoms. In some cases, rehabilitation is needed for weakness or clumsiness. This can include physical, occupational, or speech therapy.
Sometimes, medicines that help improve memory, such as those for Alzheimer disease, are used.
Seizures, also called amyloid spells, may be treated with anti-seizure drugs.
Outlook (Prognosis)
The disorder slowly gets worse.
Possible Complications
Complications of CAA may include:
- Dementia
- Hydrocephalus (rarely)
- Seizures
- Repeated episodes of bleeding in the brain
When to Contact a Medical Professional
Go to the emergency room or call 911 or the local emergency number if you have sudden loss of movement, sensation, vision, or speech.
References
Charidimou A, Boulouis G, Gurol ME, et al. Emerging concepts in sporadic cerebral amyloid angiopathy. Brain. 2017;140(7):1829-1850. PMID: 28334869
Greenberg SM, Charidimou A. Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria. Stroke. 2018;49(2):491-497. PMID: 29335334
Polster SP, Carrión-Penagos J, Awad IA. Nonlesional spontaneous intracerebral hemorrhage. In: Winn HR, ed. Youmans and Winn Neurological Surgery. 8th ed. Philadelphia, PA: Elsevier; 2023:chap 423.
Shoamanesh A, Kase CS. Intracerebral hemorrhage. In: Jankovic J, Mazziotta JC, Pomeroy SL, Newman NJ, eds. Bradley and Daroff's Neurology in Clinical Practice. 8th ed. Philadelphia, PA: Elsevier; 2022:chap 66.
Version Info
Last reviewed on: 4/25/2022
Reviewed by: Joseph V. Campellone, MD, Department of Neurology, Cooper University Hospital, Camden, NJ. Review provided by VeriMed Healthcare Network. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M. Editorial team.
