Vitamin B2 (Riboflavin)
Riboflavin
Vitamin B2, also called riboflavin, is one of 8 B vitamins. All B vitamins help the body to convert food (carbohydrates) into fuel (glucose), which is used to produce energy. These B vitamins, often referred to as B-complex vitamins, also help the body metabolize fats and protein. B complex vitamins are necessary for a healthy liver, skin, hair, and eyes. They also help the nervous system function properly.
All B vitamins are water soluble, meaning the body does not store them.
In addition to producing energy for the body, riboflavin works as an antioxidant, fighting damaging particles in the body known as free radicals. Free radicals can damage cells and DNA, and may contribute to the aging process, as well as the development of a number of health conditions, such as heart disease and cancer. Antioxidants, such as riboflavin, can fight free radicals and may reduce or help prevent some of the damage they cause.
Riboflavin is also needed to help the body change vitamin B6 and folate into forms it can use. It is also important for growth and red blood cell production.
Most healthy people who eat a well-balanced diet get enough riboflavin. However, elderly people and alcoholics may be at risk for riboflavin deficiency because of poor diet. Symptoms of riboflavin deficiency include:
- Fatigue
- Slowed growth
- Digestive problems
- Cracks and sores around the corners of the mouth
- Swollen magenta-colored tongue
- Eye fatigue
- Swelling and soreness of the throat
- Sensitivity to light
Cataracts
Vitamin B2, along with other nutrients, is important for normal vision. Early studies suggest that riboflavin might help prevent cataracts, damage to the lens of the eye, which can lead to cloudy vision. In one double-blind, placebo-controlled study, people who took a niacin and riboflavin supplement had fewer cataracts than people who took other vitamins and nutrients. However, researchers do not know whether that was due to riboflavin, niacin, or the combination of the two. More research is needed to see if riboflavin can really help prevent cataracts.
Migraine headache
Several studies suggest that people who get migraines may reduce how often they get migraines and how long the migraines last by taking riboflavin. One double-blind, placebo-controlled study showed that taking 400 mg of riboflavin a day cut the number of migraine attacks in half. However, the study did not compare riboflavin to conventional medications used to prevent migraines. More research is needed.
Autism
Preliminary research suggests that supplementation with vitamin B2, along with vitamin B6, and magnesium reduces the level of dicarboxylic acids (abnormal organic acids) in the urine of autistic children.
Dietary Sources
The best sources of riboflavin include:
- Brewer's yeast
- Almonds
- Organ meats
- Whole grains
- Wheat germ
- Wild rice
- Mushrooms
- Soybeans
- Milk
- Yogurt
- Eggs
- Broccoli
- Brussels sprouts
- Spinach
Flours and cereals are often fortified with riboflavin.
Riboflavin is destroyed by light. So food should be stored away from light to protect its riboflavin content. While riboflavin is not destroyed by heat, it can be lost in water when foods are boiled or soaked. Roasting and steaming foods preserves more riboflavin than frying or scalding your foods.
Available Forms
Riboflavin is generally included in multivitamins and B-complex vitamins. It also comes separately in 25 mg, 50 mg, and 100 mg tablets.
How to Take It
As with all medicines, check with a health care provider before giving riboflavin supplements to a child.
Daily recommendations for dietary riboflavin are as follows.
Pediatric
- Infants, birth to 6 months: 0.3 mg (adequate intake)
- Infants, 7 to 12 months: 0.4 mg (adequate intake)
- Children, 1 to 3 years: 0.5 mg (RDA)
- Children, 4 to 8 years: 0.6 mg (RDA)
- Children, 9 to 13 years: 0.9 mg (RDA)
- Boys, 14 to 18 years: 1.3 mg (RDA)
- Girls, 14 to 18 years: 1 mg (RDA)
Adult
- Men, 19 years and older: 1.3 mg (RDA)
- Women, 19 years and older: 1.1 mg (RDA)
- Pregnant women: 1.4 mg (RDA)
- Breastfeeding women: 1.6 mg (RDA)
Riboflavin is best absorbed when taken between meals.
People who do not eat a balanced diet every day may benefit from taking a multivitamin and mineral complex.
Precautions
Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a knowledgeable health care provider.
Riboflavin is generally considered safe, even at high doses. Riboflavin does not seem to cause any serious side effects. Very high doses may cause:
- Itching
- Numbness
- Burning or prickling sensations
- Yellow or orange urine
- Sensitivity to light
Taking any one of the B vitamins for a long period of time can result in an imbalance of other important B vitamins. For this reason, you may want to take a B-complex vitamin which includes all the B vitamins.
Possible Interactions
If you are currently being treated with any of the following medications, you should not use vitamin B2 supplements without talking to your health care provider first.
Anticholinergic medications: Doctors use anticholinergic drugs to treat a variety of conditions, including gastrointestinal spasms, asthma, depression, and motion sickness. These drugs may make it hard for the body to absorb riboflavin.
Tetracycline: Riboflavin interferes with the absorption and effectiveness of the antibiotic, tetracycline. All vitamin B-complex supplements act in this way. You should take riboflavin at a different time during the day than when you take tetracycline.
Tricyclic antidepressants: Tricyclic antidepressants may reduce levels of riboflavin in the body. These include:
- Imipramine (Tofranil)
- Desimpramine (Norpramin)
- Amitriptyline (Elavil)
- Nortriptyline (Pamelor)
Antipsychotic medications: Antipsychotic medications called phenothiazines (such as chlorpromazine, or Thorazine) may lower riboflavin levels.
Doxorubicin: Riboflavin interferes with doxorubicin, a medication used for the treatment of certain cancers. Also, doxorubicin may deplete levels of riboflavin in the body. Your doctor will let you know whether you need to take a riboflavin supplement or not.
Methotrexate: This medication is used to treat cancer and autoimmune diseases such as rheumatoid arthritis. It can interfere with how the body uses riboflavin.
Phenytoin (Dilantin): This medication, used to control seizures, may affect riboflavin levels in the body.
Probenecid: This medication used for gout may decrease the absorption of riboflavin from the digestive tract and increase how much is lost in the urine.
Thiazide diuretics (water pills): Diuretics that belong to a class known as thiazides, such as hydrochlorothiazide, may cause you to lose more riboflavin in your urine.
Supporting Research
Antoon AY, Donovan DK. Burn Injuries. In: Behrman RE, Kliegman RM, Jenson HB, eds. Nelson Textbook of Pediatrics. Philadelphia, PA: W.B. Saunders Company; 2000:287-94.
Bruno EJ Jr, Ziegenfuss TN. Water-soluble vitamins: research update. Curr Sports Med Rep. 2005 Aug;4(4):207-13. Review.
Colombo B, Saraceno L, Comi G. Riboflavin and migraine: the bridge over troubled mitochondria. Neurol Sci. 2014;35 Suppl 1:141-4.
Cumming RG, Mitchell P, Smith W. Diet and cataract: the Blue Mountains Eye Study. Ophthalmology. 2000;107(3):450-56.
Fishman SM, Christian P, West KP. The role of vitamins in the prevention and control of anaemia. Public Health Nutr. 2000;3(2):125-150. Review.
Head KA. Natural therapies for ocular disorders, part two: cataracts and glaucoma. Altern Med Rev. 2001;6(2):141-166. Review.
Jacques PF, Chylack LT Jr, Hankinson SE, et al. Long-term nutrient intake and early age-related nuclear lens opacities. Arch Ophthalmol. 2001;119(7):1009-19.
James. Andrews' Diseases of the Skin: Clinical Dermatology. 11th ed. Philadelphia, PA: Elsevier Saunders; 2011.
Katuzna-Czaplinska J, Socha E, Rynkowski J. B vitamin supplementation reduces excretion of urinary dicaroxylic acids in autistic children. Nutr Res. 2011;31(7):497-502.
Keligman. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Elsevier Saunders; 2011.
Kuzniarz M, Mitchell P, Cumming RG, Flood VM. Use of vitamin supplements and cataract: the Blue Mountains Eye Study. Am J Ophthalmol. 2001;132(1):19-26.
MacLennan SC, Wade FM, Forrest KM, Ratanayake PD, Fagan E, Antony J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008 Nov;23(11):1300-04.
Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J. A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis. Headache. 2007 Jan;47(1):52-57.
Maraini G, Williams SL, Sperduto RD, Ferris FL, Milton RC, Clemons TE, Rosmini F, Ferrigno L. Effects of multivitamin/mineral supplementation on plasma levels of nutrients. Report No. 4 of the Italian-American clinical trial of nutritional supplements and age-related cataract. Ann Ist Super Sanita. 2009;45(2):119-127.
Mauskop A. Alternative therapies in headache. Is there a role?. Med Clin North Am. 2001;85(4):1077-84. Review.
Ramu A, Mehta MM, Leaseburg T, Aleksic A. The enhancement of riboflavin-mediated photo-oxidation of doxorubicin by histidine and urocanic acid. Cancer Chemother Pharmacol. 2001;47(4):338-46.
Silberstein SD, Goadsby PJ, Lipton RB. Management of migraine: an algorithmic approach. Neurology. 2000;55(9 Suppl 2):S46-S52. Review.
Zhao H, Yang X, Zhou R, Yang Y. Study on vitamin B1, vitamin B2 retention factors in vegetables. We Sheng Yan Jiu. 2008;37(1):92-96.