Clues to Developing More Effective Antipsychotic Drugs Discovered
The pattern of cell signaling induced by antipsychotic drugs in a complex composed of two brain receptors linked to schizophrenia has been identified by researchers from Mount Sinai School of Medicine. The discovery should allow researchers to predict the effectiveness of novel compounds for the treatment of schizophrenia and other serious mental disorders and may accelerate the development of better antipsychotic drugs. "In the first two phases of our research we have made important discoveries about how the receptor complex forms and how it signals, as well as how drugs alter the signaling activity to treat or cause psychosis," said study co-author Miguel Fribourg, PhD, who works in the laboratory of Stuart Sealfon, MD, a study co-author and the Glickenhaus Professor and Chair of the Department of Neurology at Mount Sinai School of Medicine.
- Dr. Stuart Sealfon, Professor & Chair, Neurology, Mount Sinai School of Medicine
- Dr. Javier Gonzalez-Maeso, Assistant Professor, Neurology, Psychiatry, Mount Sinai School of Medicine
- Dr. Marta Filizola, Associate Professor, Structural and Chemical Biology, Mount Sinai School of Medicine
- Dr. Miguel Fribourg, Postdoctoral Fellow, Neurology, Mount Sinai School of Medicine
Learn more: http://www.sciencedaily.com/releases/2011/11/111123133133.htm