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Dr. Scott L. Friedman: “Drug Improves Nonalcoholic Steatohepatitis, With Caveats”

  • Medscape
  • (November 12, 2014)

A bile acid derivative, obeticholic acid (OCA), improves nonalcoholic steatohepatitis (NASH), according to a study published online November 7 in the Lancet. Incidence of NASH has increased with the obesity epidemic, affecting people with diabetes, insulin resistance, and/or hypertriglyceridemia. "The condition can smolder for decades without the patient realizing it. A liver is very resilient, so can harbor a lot of inflammation for a long time without specific symptoms," said Dr. Scott L. Friedman, Dean, Therapeutic Discovery, Professor, Medicine, Liver Diseases, Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai. Learn more