"Implicating Differences Found Between Early Onset, Longstanding Atopic Dermatitis" - Kevin Kunzmann
For the first time, researchers have found substantial differences in the initiation of early onset atopic dermatitis (AD) in pediatrics and that of the longstanding form of the disease in adults. A wide genomic analysis conducted by a team from the Mount Sinai Health System reported disparities in both lesional and non-lesional tissue in the skin of both patient groups with AD. The inflammatory-based differentiation came as a big surprise to researchers, said corresponding author, Emma Guttman-Yassky, MD, PhD, professor of dermatology, medicine, and clinical immunology, vice chair of research in the department of dermatology and director of the center for excellence in eczema at the Icahn School of Medicine at Mount Sinai. “We were quite impressed with the findings. Children had no Th1 activation and no barrier abnormalities.” The findings also bring to question the role of phenotype in the development of the atopic march in patients, Dr. Guttman-Yassky said.
- Emma Guttman-Yassky, MD, PhD, The Sol & Clara Professor, Dermatology, Clinical Immunology, Medicine, Vice Chair, Research, Department of Dermatology, Director, The Center for Excellence in Eczema, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai