• Press Release

Researchers Discover Earliest Recorded Lead Exposure in 250,000 Year-Old Neanderthal Teeth

  • New York, NY
  • (October 31, 2018)

Using evidence found in teeth from two Neanderthals from southeastern France, researchers from the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai report the earliest evidence of lead exposure in an extinct human-like species from 250,000 years ago.

This study is the first to report lead exposure in Neanderthal and is the first to use teeth to reconstruct climate during and timing of key developmental events including weaning and nursing duration— key determinants of population growth.

Results of the study were published in Science Advances, a journal published by the American Association for the Advancement of Science.

The international research team of biological anthropologists, archaeologists, earth scientists, and environmental exposure experts measured barium, lead and oxygen in the teeth for evidence of nursing, weaning, chemical exposure, and climate variations across the growth rings in the teeth. Elemental analysis of the teeth revealed short-term exposure to lead during cooler seasons, possibly from ingestion of contaminated food or water, or inhalation from fires containing lead.

During fetal and childhood development, a new tooth layer is formed every day. As each of these ‘growth rings’ forms, some of the many chemicals circulating in the body are captured in each layer, which provides a chronological record of exposure. The research team used lasers to sample these layers and reconstruct the past exposures along incremental markings, similar to using growth rings on a tree to determine the tree’s growth history.

This evidence allowed the team to relate the individuals’ development to ancient seasons, revealing that one Neanderthal was born in the spring, and that both Neanderthal children were more likely to be sick during colder periods. The findings are consistent with mammals’ pattern of bearing offspring during periods of increased food availability.  The nursing duration of 2.5 years in one individual is similar to the average age of weaning in preindustrial human populations. The researchers note they can’t make broad generalizations about Neanderthals due to the small study size, but that their research methods offer a new approach to answering questions about long extinct species.

“Traditionally, people thought lead exposure occurred in populations only after industrialization, but these results show it happened prehistorically, before lead had been widely released into the environment,” said one of the study’s lead authors, Christine Austin, PhD, Assistant Professor in the Department of Environmental Medicine and Public Health at the Icahn School of Medicine at Mount Sinai. “Our team plans to analyze more teeth from our ancestors and investigate how lead exposures may have affected their health and how that may relate to how our bodies respond to lead today.”

“Dietary patterns in our early life have far reaching consequences for our health, and by understanding how breastfeeding evolved we can help guide the current population on what is good breastfeeding practice,” said Manish Arora PhD, BDS, MPH, Professor and Vice Chairman Department of Environmental Medicine and Public Health at the Icahn School of Medicine. “Our research team is working on applying these techniques in contemporary populations to study how breastfeeding alters health trajectories including those of neurodevelopment, cardiac health and other high priority health outcomes.”

“This study reports a major breakthrough in the reconstruction of ancient climates, a significant factor in human evolution, as temperature and precipitation cycles influenced the landscapes and food resources our ancestors relied on,” said the study’s lead author Tanya Smith, PhD, Associate Professor at Griffith University.

Other key authors on the study include Daniel Green of the Forsyth Institute and Renaud Joannes-Boyau of Southern Cross University in Australia. Other institutions involved in this study include New York University, Harvard University, Australian National University, and Institut de Palentologie Humaine in France.

About The Institute for Exposomic Research

The Institute for Exposomic Research at the Icahn School of Medicine at Mount Sinai is the world’s first research institute devoted to the intensive study of the exposome, or the totality of environmental influences on human health. The mission of the Institute is to understand how the complex mix of nutritional, chemical, and social environments affect health, disease, and development later in life and to translate those findings into new strategies for prevention and treatment. For more information, visit http://icahn.mssm.edu/exposomics.


About the Mount Sinai Health System

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with 48,000 employees working across eight hospitals, more than 400 outpatient practices, more than 600 research and clinical labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time—discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it.

Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 9,000 primary and specialty care physicians and 11 free-standing joint-venture centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida. Hospitals within the System are consistently ranked by Newsweek’s® “The World’s Best Smart Hospitals, Best in State Hospitals, World Best Hospitals and Best Specialty Hospitals” and by U.S. News & World Report's® “Best Hospitals” and “Best Children’s Hospitals.” The Mount Sinai Hospital is on the U.S. News & World Report® “Best Hospitals” Honor Roll for 2024-2025.

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