• News

"A Modifying Autoantigen in Graves' Disease" - Marie Benz

  • Medical Research
  • New York, NY
  • (March 31, 2019)

The receptor for thyroid stimulating hormone (TSH) is a major antigen for Graves’ disease and patients have unique antibodies to the TSHR which stimulate excessive thyroid hormone secretion, said Terry Davies, MD, co-director of The Thyroid Center at Mount Sinai Union Square, in an abstract presented at ENDO 2019, the Endocrine Society’s annual meeting. “We have characterized a variant TSHR called v1.3 which is a splicing variant which we find expressed in thyroid, bone marrow, thymus and adipose tissue and incorporates an intronic sequence which is fully translated.” 

— Terry Davies, MD, Professor, Medicine, Endocrinology, Diabetes and Bones Disease, Icahn School of Medicine at Mount Sinai, Co-Director, The Thyroid Center, Mount Sinai Union Square

Learn more