"Coronary Stent Patients May Not Need Long-Term Aspirin"
High-risk patients undergoing coronary stent procedures may not require long-term aspirin use after stent placement, Mount Sinai researchers report in a groundbreaking study. “This pivotal, first-ever study to withdraw aspirin in complex patients with coronary stents underlines the importance of bleeding avoidance strategies for targeted care. We showed that withdrawal of aspirin after three months in patients already on a potent antiplatelet regimen (ticagrelor) reduced bleeding significantly without the harm of increasing death or heart attacks,” said Roxana Mehran, MD, director of interventional cardiovascular research and clinical trials at the Zena and Michael A. Weiner Cardiovascular Institute at the Icahn School of Medicine at Mount Sinai. “As an academic, investigator-initiated global trial, this effort represents the concerted and enthusiastic support of partners and collaborators within the United States and abroad who were committed to answering an important and clinically relevant question,” said Usman Baber, MD, MS, assistant professor of medicine and cardiology at the Icahn School of Medicine at Mount Sinai. “This groundbreaking study enhances Mount Sinai Heart’s excellence in the field of interventional cardiology,” said Valentin Fuster, MD, PhD, director of Mount Sinai Heart and physician-in-chief of The Mount Sinai Hospital. “The TWILIGHT trial is a landmark trial which will change our PCI practice by eliminating aspirin after three months in patients on ticagrelor with resultant lower vascular bleeding and no effect on ischemic endpoints,” said Samin Sharma, MD, director of clinical and interventional cardiology at The Mount Sinai Hospital.
— Valentin Fuster, MD, PhD, Director, Mount Sinai Heart, Physician in Chief, The Mount Sinai Hospital, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai
— Roxana Mehran, MD, Director, Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A. Weiner Cardiovascular Institute, Professor, Medicine, Cardiology, Population Health Science and Policy, Icahn School of Medicine at Mount Sinai
— Usman Baber, MD, MS, Assistant Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai
— Samin K. Sharma, MD, Dean, International Clinical Affiliations, Professor, Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, Director, Clinical and Interventional Cardiology, The Mount Sinai Hospital
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