"Mood, Anxiety Disorders And PTSD Associated With Shared Brain Phenotypes" - Joe Gramigna
Mood disorders, PTSD and anxiety disorders share brain phenotypes that may serve as targets for interventions, according to results of a meta-analysis by researchers at the Icahn School of Medicine at Mount Sinai and published in JAMA Psychiatry. “Negative mood states, such as depression and anxiety, are part of the normal range of emotions, especially when in the face of loss or challenges,” said Sophia Frangou, MD, PhD, professor of psychiatry at Icahn School of Medicine at Mount Sinai. She added, “In healthy individuals, the brain's control network is activated to regulate such emotions so they do not become pathological. However, in people with mood and anxiety disorders, such negative moods are unprovoked, pervasive and persistent. This study helps to explain why these mood states persist and may be linked to dysfunction in the brain's control network.”
— Sophia Frangou, MD, PhD, Professor, Psychiatry, Icahn School of Medicine at Mount Sinai