Comprehensive Patient-Centered Home-based Care Coaching for COPD Self-management
The Icahn School of Medicine at Mount Sinai will conduct a randomized controlled trial of
a self-management support intervention for predominantly minoritized and low-income
adults with chronic obstructive pulmonary disease (COPD). The trial will focus on
comprehensi...
Age: 40 years - 66+
Gender: All
Behavioral Therapy for Crohn's Disease
People living with Crohn's disease (CD) experience psychological and emotional symptoms,
in addition to known chronic and disabling physical symptoms, which prevent them from
living their life to the fullest (flourishing). Depression and anxiety are experienced by
30...
Age: 18 - 65 years
Gender: All
Lamivudine for Solid Tumors
Single arm, set dose clinical trial of Lamivudine for Relapsed Refractory Solid Tumors.
Accrual 6-24 patients, within 2 years, study completion within 3 years at Mount Sinai
Health System.
Primary Objective:
For Phase 1b to determine the safety and tolerabilit...
Age: 18 years - 66+
Gender: All
The Prevent Coronary Artery Disease Trial
Despite increasing evidence that exposure to cardiovascular risk factors (CVRF) at an early age increases the prevalence of subclinical atherosclerosis and is associated with a greater risk of cardiovascular events later in life, there is a lack of randomized trial evid...
Age: 30 - 50 years
Gender: All
A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease
which includes the forming of lumps, abscesses and scars in areas of the skin such as
under the breasts, under armpits, inner thighs, groin and buttocks. This study will
compare lu...
Age: 16 years - 66+
Gender: All
Longitudinal Monitoring of Inflammatory Bowel Disease Using a Sweat Sensing Wearable Device (Sweat Sensor Study)
The Sweat Sensor Study at Mount Sinai aims to measure and monitor markers of inflammation and the immune system, such as C-reactive protein and calprotectin, continuously in the sweat using a wearable sweat sensing device. Our hope is that this wearable device will even...
Age: 18 years - 66+
Gender: All
PIvotal Trial of the KARDION Cory P4 MechANical Circulatory SupporT SystEm
This purpose of this trial is to demonstrate 30 day safety and effectiveness outcomes of
the KARDION CORY P4 System in subjects who require hemodynamic support during a high-risk
PCI procedure.
Age: 18 - 90 years
Gender: All
The Women With Inflammatory Bowel Disease and Motherhood (WIsDoM) Study - A Study Focused on Female Fertility and IBD
View WIsDoM Study Promo Video
What is the purpose of the study?
Many patients with Crohn’s disease or ulcerative colitis are women who are diagnosed with the disease during peak childbearing years. Both patients and providers frequently ask whether IBD, IBD...
Age: 18 - 45 years
Gender: Female
Resilient Together for Dementia
The proposed study will establish the feasibility, acceptability and credibility of a novel
live video dyadic resiliency intervention, Resilient Together for Dementia (RT-D), aimed at
preventing chronic emotional distress and preserving quality of life among dyads a...
Age: 65 years - 66+
Gender: All
Assessment of Supportive Care and Educational Needs to Guide Quality Care Improvements for Patients With Locally Advanced and Metastatic Bladder Cancer
The overall goal of this study is to facilitate care improvements for bladder cancer patients with locally advanced or metastatic disease by designing and evaluating a patient need assessment screening tool to be used, in the future, as standard screening measure. Adult...
Age: 18 - 89 years
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Women
This is a research study in women to compare the outcomes of two procedures that restore
blood flow to the arteries of the heart. In one procedure the blockages are ballooned and
then stented with a small wire mesh tube through a small incision in the wrist or the
gr...
Age: 18 years - 66+
Gender: All
REvascularization CHoices Among Under-Represented Groups Evaluation: The RECHARGE Trial - Minorities
This is a research study in minorities to compare the outcomes of two procedures that
restore blood flow to the arteries of the heart. In one procedure the blockages are
ballooned and then stented with a small wire mesh tube through a small incision in the
wrist or t...
Age: 18 years - 66+
Gender: All
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Renal Function in Adults Living With Obesity (TRIUMPH-OUTCOMES)
The main purpose of this study is to determine if retatrutide can significantly lower the
incidence of serious heart-related complications or prevent the worsening of kidney
function. The trial will enroll adults with body mass index 27 kg/m^2 or higher and
Atheroscl...
Age: 45 years - 66+
Gender: All
Ritlecitinib in Patients With Keloids or Those Undergoing Keloidectomy
Keloids are common, benign cutaneous overgrowths that manifest clinically as raised,
hypertrophic, often hyperpigmented lesions which are formed in response to dermal injury
or idiopathic stimuli. Although keloids are a common disease, it's exact incidence and
preval...
Age: 18 years - 66+
Gender: All
A Study to Assess the Efficacy, Safety, and Pharmacokinetics of FNP-223 to Slow Progression of Progressive Supranuclear Palsy (PSP)
PROSPER trial is a trial to assess the efficacy of FNP-223 in slowing disease progression
in participants with PSP as measured by the PSP Rating Scale (PSPRS) over 52 weeks and to
assess the safety and tolerability of FNP-223 for 52 weeks in participants with PSP.
Age: 50 - 80 years
Gender: All
Crohn's Disease: Efficacy, Safety, and Pharmacokinetics of Upadacitinib in Pediatric Subjects With Moderately to Severely Active Crohn's Disease
Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness,
swelling), in the digestive tract, most often affecting the bowels. It can cause many
different symptoms including abdominal pain, diarrhea, tiredness, and weight loss. This
stud...
Age: 2 - 17 years
Gender: All
High Fructose Diet, the Gut Microbiome, and Metabolic Health
Americans commonly consume excess amounts of dietary fructose. Added fructose has been
shown to have an adverse impact on metabolic health, including increased insulin
resistance and type 2 diabetes (T2D) risk. However, the mechanisms that link dietary
fructose and m...
Age: 25 - 45 years
Gender: All
A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a)
The purpose of this study is to evaluate the efficacy of lepodisiran in reducing
cardiovascular risk in participants with high lipoprotein(a) who have cardiovascular
disease or are at risk of a heart attack or stroke. The study drug will be administered
subcutaneousl...
Age: 18 years - 66+
Gender: All
MiroliverELAP® for the Treatment of Acute Liver Failure: a Phase 1 Trial
The clinical trail will assess the safety of miroliverELAP for the treatment of acute
liver failure without underlying chronic liver disease. miroliverELAP is an external
liver assist combination product consisting of a single-use MIRO-001 bioengineered liver
graft a...
Age: 18 - 80 years
Gender: All
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel
disease (IBD), who often experience a relapsing disease course, is an essential component of
care. Improving IBD disease control is linked to increased health-related quality of l...
Age: 18 years - 66+
Gender: All