"Early Control Of Crohn’s Modifies Disease Course, Study Indicates" - David Wild
Seizing endoscopic control of Crohn’s disease early in the course of the illness can profoundly reduce the likelihood of future complications, according to researchers at the Icahn School of Medicine at Mount Sinai. “One group of patients was managed under a “tight control” and “treat-to-target” paradigm, in which clinical symptoms along with biomarkers such as C-reactive protein and fecal calprotectin; endoscopic findings helped guide treatment toward mucosal remission. The other group had their treatment guided by symptoms alone with the goal of clinical remission, as is commonly done,” said co-lead researcher Ryan Ungaro, MD, assistant professor of medicine and gastroenterology at the Icahn School of Medicine at Mount Sinai. He added, “Our findings validate the recommended treatment strategies of early intervention and a treat-to-target approach, and they demonstrate that disease modification is possible for Crohn’s disease patients if we can achieve early remission.”
— Ryan C. Ungaro, MD, Assistant Professor, Medicine, Gastroenterology, Icahn School of Medicine at Mount Sinai